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jama glp 1 Genetic differences may help explain why some patients experience greater weight loss or more adverse effects on #GLP1 receptor agonists such as #semaglutide or #tirzepatide, according to a new genome-wide association study

Marsoni M251S
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GLP 1 medications aren't just about weight loss they're changing heart health. Research shows GLP 1s can lower the risk of heart attack and stroke, even for some people without Frmacos basados en GLP 1: mecanismos implicados en el tratamiento de la obesidad Medicina Clnica Professor Ana Santos Rutschman weighed in on recent lawsuits alleging popular GLP 1 drugs can cause serious injuries and how these cases influence public trust, the market and risk warnings for these medications. Zepbound (Tirzepatide) GLP 1 injection Nurx The GLP 1 Era: Why These Intestinal Peptides Are Reshaping Modern Medicine GLP 1 Receptor Agonists in Heart Failure Management CFR Journal
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4.0 ★★★★★
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nubbles
Grantham, US
★★★★★ 5
Great stimulation for a 'busy' pup
Color: Blue, Color: Blue
I’ll admit I was a little skeptical since my German Shepherd is well over the recommended weight limit for this ball, but it’s been a huge hit. Even though it’s technically for smaller breeds, it has held up remarkably well so far. I’ve mostly kept it on the gentle mode, and that’s more than enough to grab her attention and keep her occupied for quite a while. The design is actually much tougher than the warnings suggest; the two halves screw together so securely that she hasn't been able to pry it open, which is impressive for a tough chewer. It’s been a great way to keep her mentally engaged indoors without worrying about the toy falling apart immediately.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 2, 2026
C
customer reviewer
Natrona Heights, US
★★★★★ 4
Recommended for Small, Mellower Dogs, not the destructive, chewy kind
Color: Blue, Color: Blue
My dog loved this ball, maybe a little too much. He attacked it like it was a wild animal and left teeth marks and tears in the outer plastic. I decided to give it to my cats instead, who initially were very intrigued by it. The buff kitty even chirped to see it. He would roll around with it as it vibrated and hopped, but after a while he wasn’t that interested. I think I can get them to play with it if I don’t use it with them every day, maybe wait a few weeks between playtimes. Perhaps it is a little too large for cats. My dog, who is less than 30 lbs., might be too big for it, or maybe just his mouth is, or maybe because he’s a Boston Terrier and he always feels like it’s his duty to destroy all toys (all my Bostons were like that). But I don’t think I will let him have it again. Maybe a toy breed or puppy might be more of the appropriate size for this ball. Or someone who isn’t as destructive. The instructions are almost unreadable because the text is so small. I couldn’t understand what I was supposed to do with the “installation process.” I did figure out how to turn it on and off by myself, however. There are four modes when it is on: gentle, normal, active, and lighting only (no vibration). As a human, it is a fun thing to watch, even if it is just for the light show.
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Reviewed in the United States on May 6, 2026
D
Verified Purchase
Dfg
Houston, US
★★★★★ 5
Good to for korgi
Dog loves it
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Reviewed in the United States on May 23, 2026
T
Verified Purchase
Traveling Carpenter
West Palm Beach, US
★★★★★ 4
Battery so so
Each charge doesn’t last very long, but my dog likes it when it does.
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Reviewed in the United States on April 9, 2026
S
Verified Purchase
Samael
Alexandria, US
★★★★★ 1
SMELLS MUSTY
Opened it up for our pup on his bday and it smelled like pure mold. We had to throw it out because it was just terrible smelling and we didn't want our pup to even put it in his mouth!
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Reviewed in the United States on March 2, 2026

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